Q & A

Questions & Answers

If you have any questions about PCOS, it’s effects or it’s treatment that you would like an answer to, please leave them in a comment on this page and I will do my very best to provide you with an answer in as short a time as possible.

In the meantime, I hope you will learn something new and useful in one of the questions already answered:


31 Responses to Q & A

  1. Jenee says:

    Can you send copies of all the studies that have been done on DCI in the medical and scientific journals or clinical trials so that I can educate my RE at my next appt.

  2. Jenee says:

    Nevermind. I found the requested information under Natural Treatments and not under News and Research.

  3. Misty says:

    Hi Anne. I have been taking DCI for about 2 months now and so far I feel great, I noticed a difference in my energy level within a week. I have been considering adding Maca Root to my regimen to help regulate my hormones. Do you know if it is safe to take with the DCI or of any possible side effects of taking the two together? I have been unable to find any info on this. Thanks for all the wonderful information on your site!

    • My PCOS Info says:

      Hi Misty,

      Thank you for the feedback about your experience with D Chiro Inositol – I’m so glad it had such a strong and positive result for you. I personally think that the herb Vitex Agnus Castus is a better choice for hormone regulation in PCOS and there are a large number of women who safely take both DCI & Vitex with no adverse effects. I have read conflicting information with respect to Maca. Some women have found it very helpful, others have found it worsened their symptoms. From what I understand of the mechanism of action of Maca and DCI, there should not be any negative interaction between the two, though, so if you have a preference for Maca over Vitex, there’s no reason why you shouldn’t try it. Just monitor your results and if you think you are one of the women you don’t respond well to Maca, stop taking it.

      Another important factor to consider when aiming to regulate hormones, is the role of the liver. The liver metabolises away excess hormones, as is seen in PCOS, so you want your liver to be functioning in an ideal, efficient way. Castor Oil Packs and St Mary’s Thistle will both support optimal liver function. In fact, a compound isolated from St Mary’s Thistle, silymarin, is sometimes used by chemotherapy patients in hospital to help protect the liver from the toxic effects of the chemotherapy drugs!

      I’m so glad you find the site informative, I hope this information helps.

      All the best,


  4. Tasia says:

    Hi Anne. I have been reading your website and have found it to be very helpful. I was wondering if you would be able to send me a copy of the ebook:’The Natural Diet Solution for PCOS and Infertility’ . I have been trying to purchase it from the website, but it wont accept my card. I do hope that you will be able to accomodate me. Thank you.


  5. Tamara Fingerit says:

    Could you please let me know if you can ship DCI to Dubai (UAE) and how much it will cost to ship 100g?


  6. Sara says:

    Hi Anne,
    What is the best way to consume DCI and when? Also what can I try to encourage menstration ?

    Thank you

    • My PCOS Info says:

      DCI is most effective when you take the right amount, at the right time and frequency, consistently.

      Clinical results have found that the best outcomes are obtained by women taking:


      20 mg or more of DCI per kg of bodyweight per day.

      In divided doses

      30 mins before meals on an empty stomach

      With a full glass of water

      Starting first thing on waking in the morning

      Another way to increase the effectiveness of DCI is take it with Manganese. Studies have found that DCI is twice as effective at lowering elevated blood sugar levels when it is taken in conjunction with the mineral Manganese.

      There are three ways you can attack the hormonal imbalance which accompanies PCOS and they work best if you use them all together.

      1. Increase your body’s sensitivity to insulin & control blood sugar levels.
      2. Support the liver in clearing excess oestrogen from the system
      3. Support your endocrine system to regulate your reproductive hormones

      You might look into Vitex Agnus Castus to help regulate your hormones and encourage the return of an absent menstrual cycle:


      Castor Oil Packs also helped me: http://mypcos.info/1/treatments/natural/co-heat-packs/

      If after 6 months you still have not had a period, you could consider getting a prescription for micronized progesterone (bioidentical) in a cream or pessary and using it from the 14th – 28th of each month for a few months. This should help to ‘reset’ your system.

      Of course, the basis of any effective PCOS treatment protocol is a controlled carbohydrate diet and regular exercise program. Gentle exercise with moderate strength training is probably best, as strenuous exercise can increase cortisol levels which would have a negative impact on PCOS.

      I hope this information is helpful.

      Kind regards,


    • My PCOS Info says:

      Hi Sara,

      DCI is best consumed on an empty stomach, beginning first thing in the morning and taking regular top up doses throughout the day, as it is water-soluble and quickly excreted. A simple way to achieve this is to take a quarter of your daily dose first thing in the morning half an hour before breakfast and then put the rest into a water bottle and sip on it between meals throughout the day. Vitex agnus castus is often helpful for encouraging female reproductive hormones back into order, but there are many different options, depending upon your individual circumstances.

  7. Marikath says:


    First of all I would like to say thank you for putting up this website! I plan to buy DCI. I am a lean woman, 4’11 in height with PCOs, 98 lbs.

    Do you think it is safe to take D-Chiro-Inositol with the following?

    (Regular) Inositol – 500 mg once daily

    Folic Acid – 800 mcg once daily

    Vitex Fruit (Chaste tree) – 400 mg 1-3 x daily

    NAC N-Acetyl Cysteine Selenium Molybdenum – 600 mg 1 capsule 2x daily – (Some form of an antioxidant that is beneficial for PCOS)

    Tri-Chromium Cinnamon – 500 mcg once daily – (I read that chromium and cinnamon have some effect with insulin and glucose, but I am not sure if it would overlap with the functions of DCI or complement it. But they’re known to have beneficial effects to PCOS women.)

    Saw Palmetto Standardized Extract – 160 mg 1 gel 2x daily

    Current vitamins I am taking once daily:
    Omega 3 Fish Oil 1000 mg with 300 mg Active EPA/DHA
    Ascorbic Acid 500 mg

    Please do let me know if it is safe to take the above mentioned supplements with DCI or not and whether it is better to “space” the time instead when taking the supplements.

    Thank you very much!


    • My PCOS Info says:

      Hi Marikath,

      It is fine to take DCI with those things. I would recommend taking it with the myoinositol, vitex and saw palmetto on an empty stomach in the morning.

      Cinnamon and chromium will complement the action of DCI.

      As an aside, Saw Palmetto is best taken as a single dose in the morning, and the minimum effective dose is 320 mg. It has been suggested that a dose of up to 640 mg may be appropriate if symptoms are more severe.

      Your supplement regime sounds good and quite well thought out. My only comment would be that the studies I have seen found an effective dose for N-Acetyl Cysteine to be 600 mg 3 times per day not twice and that Vitex is also best taken as a single dose first thing in the morning rather than spaced throughout the day.

      If you have any more questions please let me know. I’m here to help.

      Kind regards,


      • rio says:

        Hi i have pcos i miss my period in a month and then next month i will get it. but i want to get my period every month bec i feel like im not losing my weight even i do exercise. before im using BC named althea in (Philippines brand) no negaive side effect for me like vomitting and headeach etc. vitamin C and E for 6 month. then i stop taking BC bec i get oppurtunity to work abroad and there is no athea here when i try to yasmin, yas and diane i get vomitting and headeach then i stop taking it. now it been 1 year without BC. but i always missed my period. i take vitex now but still my period is late. i wonder if vitex folic acid inositol can help me to regulate my cycle? Can i take it all in everyday ?

  8. Mark says:

    Important info-Saw Palmetto Men, Use at least 400mg per day or it won’t work for you!

  9. Lauren says:

    Hi I too have PCOS and have been taking agnus castus along with folic acid after food in 2 1000mg tablets. After a week this brought on a period after not seeing for 8 months. Is this safe to continue taking as at first it worried me, not seeing one for such a long time then after a week I bled. Thanks

    • My PCOS Info says:

      Hi Lauren,

      Vitex agnus castus is considered to be very a safe supplement with virtually no side-effects. It does, however, tend to take several months for the effect to build up, so it is highly unlikely that your period can be attributed to your new supplements. I’m not aware of folic acid having any effect on PCOS/menstrual cycles. It is likely that the period coming on just after you started these supplements was a coincidence, however, long-term Vitex supplementation has been shown to help significantly in regulating the menstrual cycle of women with PCOS and increasing their fertility. D-chiro inositol also works very well with Vitex, as it addresses the cause of the hormonal imbalance in PCOS, whilst vitex helps give the hormones an extra nudge at normalisng more quickly than just DCI alone. You can buy DCI here.

      If you are taking folic acid because you are trying to conceive, I would encourage you instead to try and get 400 – 800 mcg of folate, rather than folic acid, from your diet as this has been shown to be a healthier option. Folic acid is a synthetic form of folate and requires metabolism by the liver before it can be utilised in its active form. Unmetabolised folic acid has been found in the blood of people who have taken folic acid supplements or even foods fortified with it and there have been several studies now that have found a link between folic acid supplementation/fortification and an increased risk of various forms of cancer. There is good evidence that 800 mcg of folate per day is beneficial for women of childbearing age to reduce the risk of neural tube defects.

      Foods which are high in folate include green leafy vegetables such as romaine lettuce, spinach, asparagus, turnip greens, mustard greens, parsley, collard greens, broccoli, cauliflower, beets, and lentils as well as calf’s liver and chicken liver.

      Chris Kresser has done a good comparison of folate vs folic acid here.

      If you have any more questions about PCOS please let me know. I’m here to help.


  10. Tanya says:

    Hi Anne,

    I’m a 22 year old female with slight hirutism , I’m 5’2 and weigh 132 pounds.
    I was diagnosed with PCOS in 2009 and have been on medication for it since then.I took Diane 35 for two years since I had severe acne and got my period only when I took the pill. Starting this year I changed my OBGYN and she has put me on metformin 500mg only.However I haven’t gotten my period since the past 6 months and my acne has also started to resurface. I do not want to go back to Diane because of it’s increased side effects. Could you please suggest a dosage of Vitex and DCI that I could take?
    Thanks a ton

    • My PCOS Info says:

      Hi Tanya,

      Thank you for your comment, I’m glad you have found the site helpful.

      The most commonly recommended starting dose for DCI is 20 mg per kg of bodyweight. 132 lb = 60 kg, so for you this would be 1200 mg.

      600 – 1000 mg of Vitex once per day in the morning is usually appropriate in PCOS.

      Have you had your vitamin D levels checked? Also chromium, magnesium, manganese and omega three fatty acids (such as are found in olive oil, fish oil, krill oil etc) are beneficial for PCOS.

      If you have any more questions, please let me know. I’m here to help.

      Kind regards,


  11. santhakumari says:

    ovarian drilling is useful to recover from pcod ? one doctor advising me to do ovarian drilling to get rid of pcos. kindly help me. can i get my periods regularly once i done this surgery ?

    • My PCOS Info says:

      Ovarian drilling is very rarely performed in PCOS these days as it has a very limited effect. It will never get rid of PCOS, but it can be helpful as a last resort, to temporarily restore ovulation for a few cycles if pregnancy is desired and all other means have failed. Although there is still much to learn about PCOS, it appears that the root cause of the disorder lies in a defect or defects in the metabolism of d-chiro inositol (DCI) and d-chiro inositol inositol phosphoglycan (DCI-IPG). The molecules are involved in insulin signalling within the cells of the body and without them functioning properly, glucose utilisation is impaired, and this then results in an increase in production of the hormone insulin, which in turn affects the hormones produced by the ovaries and disrupts the female reproductive cycle.

      What Causes PCOS?

      The only way to successfully manage PCOS is to stop this cascade of metabolic and hormonal abnormalities as close to the beginning as possible. For many women with PCOS, the most effective means to do this, is to add D-chiro inositol to their diet every day. It can be purchased here in powder form and tastes very similar to sugar.

      Buy DCI – d-chiro inositol

      What is DCI and How Does D-Chiro Inositol Work?

      There is an article here explaining how ovarian drilling works and its limitations in PCOS as well as the risks associated with the procedure.

      Ovarian Drilling – A surgical treatment option for PCOS

      • santhakumari says:

        really thank you for your timely response. your site is very informative about pcod. here in tamilnadu, india docutors are giving metformin -500 mg twice a day for PCOD treatment. i have been taking nearly 2 years. but i am raising lot complications, dark patches on my skin, hirrutism, thinning of hair, my pregnancy attempts failed. what can i do now ? pls. give your valuable opinion and prescription.

        • My PCOS Info says:

          You are most welcome. Metformin is very commonly prescribed in Western countries for PCOS as well, though newer research is finding that it may perhaps have some very unintended side effects in relation to women’s fertility. I didn’t respond well to it at all, it seemed to make my very mild case of PCOS very much worse. I have found that two of the best treatments for PCOS available at the moment are D-chiro inositol and a newer entry to the market, Glucorein-PCOS.

          You can read about both of them here:



          and you can buy them both through the shop here:


          If you have any questions about PCOS or either product that is not explained in the articles, please let me know. I’m here to help and happy to answer any questions that you may have.

          The complications you describe indicate that either the metformin is not working for you, or the dose is not high enough. Dark patches on your skin are most likely acanthosis nigricans. The body is unable to metabolise excess insulin, so it deposits it into the skin so it does not disrupt the body processes any more, causing dark velvety patches usually around creases like the back of the neck, front of the neck, under arms, breasts, groin, knees etc. Hirsutism and thinning of the hair are also likely related to elevated insulin levels, which in turn cause the theca cells in the ovaries to produce excessive amounts of the male steroid hormone testosterone.

          All the very best,


  12. noof says:

    I was diagnosed with pcos a few months ago, but i think i had it much earlier.

    My clear symptom is a prolonged period (10 days) Have had this for almost two years so i think i am not ovulating
    I also have unwanted hair in my chest and face.

    I am thinking of trying either vitex or maca,but I cant really decide. I have a regular period, meaning it comes every 29 days as an average, but it lasts longer than average. Will vitex mess my cycle up? Should I opt for maca instead? I ve read somewhere that vitex is a much recommended herb for boosing fertility for pcos sufferers.


  13. Me says:

    Hi Anne,
    I’m 72kgs (post having 2 bubs) and have PCOS and was wondering how much the max dose of inositol and d Chiro inositol I should take would be and when I should take it. I used to weigh 60kg and would like to lose the weight again.
    I also take 1200mcg per day of Chromium with vit d, zinc and magnesium. Should I add anything to these? Is there a supplement avail in Australia that combines all of the PCOS helpful supplements together?
    What would you suggest is the cheapest way for me to purchase the inositol and d Chiro inositol together? I live in Canberra Australia.
    Mel 🙂

    • My PCOS Info says:

      Hi Mel,

      Thank you for your enquiry. The recommended dose of DCI (d-chiro inositol)is 20 milligrams per kilogram of bodyweight per day, so for a 72 kg woman that would be 1440 mg.

      The dose of myoinositol used in studies for the treatment of PCOS is 4 grams per day, irrespective of weight.

      Your other supplements are quite comprehensive and should be helping your insulin sensitivity already. Please make sure you are having your vitamin D levels checked now and then to ensure that the amount you are taking is both adequate and not in excess of your requirements. I have never seen a supplement anywhere that contains an optimal formula for PCOS, though this could partially be attributed to the fact that PCOS has an array of different presentations and most women prefer to put together a regime that specifically meets their own needs.

      You can buy DCI and Myoinositol from here: My PCOS Info – SHOP and discounts are available for larger purchases, or joining a regular subscription plan. My prices are the cheapest in the world, to the best of my knowledge and I’m located in NSW.

      If there’s anything else I can help you with, please let me know. I’m here to help.

      Kind regards,


  14. daphne says:

    Hi Anne. I’m 21 and I’ve been diagnosed with pcos a month ago and I’ve been put on 500mg metformin twice daily and I was wondering if I could take vitex and saw palmetto in addition to the met. as well ??

  15. Sue says:

    I have PCOS and during a recent trip was surfing this site for various nutrients that may help. I read an article about a nutrient that some people can’t absorb properly. Resulting symptoms are non – PCOS ovarian cysts and migraines. Then there was something – maybe immune problems? – that lead to increased risk of cancer.

    My sister died of breast cancer last year. She had had terrible problems with migraines through 20’s – 30’s. She had ovarian cysts, 2 of which had to be surgically removed and symptoms similar to my PCOS< but her Dr always said she didn't have PCOS.

    She died of breast cancer. The similarity was scarry and upsetting and I put it aside.

    Her daughter, my niece, has terrible migraine problems. I meant to share the article with her when I got home, but can't find it again. Does it ring a bell with anyone?

    • Sue says:

      BTW -I seem to remember if I went in one way, I got a brief explanation of deficiency symptoms, but going in another gave me a much broader description – its this broader one that I’m looking for but can’t find.

  16. shirley says:

    Hi Anne,

    II am 34 years old with weight of 62kg; I have PCOS and y testosterone level was high,
    I am using saw palmetto, vitex, GTF chromium , folic acid and milk thistle and i am going to add DCI and NAC, please let me know is it safe to use all of them together!?
    also please let me know are they safe if I am Trying to get pregnant!!!

    I am really worry! suffering from acne and unwanted hair,
    Please advise,

  17. Chrissy says:


    I have been bleeding non stop for 3 months now. We saw during an ultrasound that I have PCOS. It,s bizarre because all my blood tests came back normal! No hormonal imbalance although I have been suffering from hot flashes day & night , acne, hardcore PMS and water retention and a mild depression.I have also started suffering from chronic sinus infection, UTI and yeast infection! (??) which all seems to indicate that I have insulin resistance. I started bleeding non stop and all this occurred at the same time. No such thing as a coincidence.

    I have started doing the Dr Natasha Turner CLEAR hormonal detox and it has helped a bit with my PMS but am thinking of taking Vitex & myo-inusitol as well. Thoughts? pls tell me there is hope…

  18. Jeff Province says:

    I¡¦ve recently started a blog, the info you offer on this site has helped me greatly. Thanks for all of your time & work.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: