Why Does D Chiro Inositol Work for Some Women & Not Others?

From Tara:

“Why Does DCI Work for Some Women & Not Others?”

Whilst the science behind how DCI works is compelling and provides us with great insight into the mechanism of insulin resistance and PCOS, it is not a magic bullet. Every human being is unique in their physiology thus no two people will ever suffer from the same disease in exactly the same way. On top of physiological idiosyncrasies we have the influence that our lifestyle choices make on our health.

A study by Dr Nestler, published in 2008 in Metabolism Clinical and Experimental 57 (2008) 1390–1397 postulates that there may be multiple defects in DCI-phosphoglycan metabolism resulting in the same thing – Insulin Resistance.  Although this study was cut short due to a sudden unavailability of the study drug – DCI, it found that in this particular cohort of women, when they were supplemented with 3000 mg of DCI per day it did not have the expected (and previously found in other studies) result of increasing the release of DCI-IPG the active form within the body tissues. They hypothesize that if one is deficient in DCI then supplementation will address that and resolve the insulin resistance, however if one is not deficient in DCI, but has a defect in DCI-IPG metabolism then mere supplementation will not address the underlying problem.

With insulin resistance (IR) and polycystic ovarian syndrome as well as other related issues such as Syndrome X, Metabolic Syndrome, Type II Diabetes Mellitus etc, the effects of exercise are particularly important. When we exercise we increase our cellular receptivity to insulin, allowing us to utilise the carbohydrates from our food with much lower insulin levels. This is of vital importance in managing IR. The other very important tool in managing IR is to keep both the glycaemic load (total amount of carbohydrates you consume) and the glycaemic index of foods (how quickly the carbohydrates in the food are absorbed into your blood stream) low. Everybody is different and the amount of carbohydrates that you can safely consume will differ depending upon how much exercise you do, your weight, the degree to which you are insulin resistant and many other factors, however as a basic guideline it would be safe to say that eating in excess of 150 grams of carbohydrate per day will not be beneficial. Some women with PCOS restrict this amount down as low as 20 grams per day, though for many this will be too extreme. Others if they are very very fit and lead a very active lifestyle can consume as much as 250 grams – but these will all be from very low GI sources such as vegetables, fruits and whole grains.

A general rule for everybody whether they have insulin resistance or not is to eat as much fresh, unprocessed food as possible – fresh, live foods that look exactly the same as when they were picked. The less processed food we eat, the healthier we will be, and this goes for every single person on earth. As an added bonus, the less processing and packaging that has gone into our food, the lower the carbon footprint will be and the less impact it will have on the earth.

The research done to date on both DCI and PCOS indicates that if you:
*Limit your carbohydrate intake
*Increase your fibre intake
*Regularly engage in exercise
*Drink plenty of water
*Take an appropriate amount of DCI
*Ensure that your Vitamin D levels are adequate

Then you will have the best chance of improving your health and fertility.

I hope this information has been of use to you.  Best of luck!


3 Responses to Why Does D Chiro Inositol Work for Some Women & Not Others?

  1. shida says:

    How do you determine how much DCI one should take?? Thanks

    • My PCOS Info says:

      Hi Shida,

      The effective dose of d-chiro inositol does vary somewhat between individual women, but clinical results indicate that a starting dose of 20 milligrams of DCI per kilogram of bodyweight is appropriate for most.

      For a woman who weighs 132 lb or 60 kilograms, this would therefore be 1200 mg of DCI per day. As many women with PCOS are also overweight, I’ll give a few more examples: 90 kilograms or 198 lb would mean a dose of 1800 mg per day. 120 kg or 264 lb would mean a dose of 2400 mg per day.

      Some women are able to taper the dose down to 10mg per kg after a few months when their symptoms subside, others find that they need to increase the dose before they see significant improvement in their symptoms. I have personally taken as much as 70 mg per kg and I did see better results at that level, but I decided to go back down to just over 20mg/kg because of the cost.

      But, as a general rule 20 mg per kg is a good starting point.

      If you have any more questions about DCI or PCOS, please let me know.

      Kind regards,


    • My PCOS Info says:

      Hi Shida,

      Everyone is different, so it’s partly trial and error, but clinical results indicate that a dose 20 mg per kilogram of bodyweight is a good place to start. Some women need as little as 10 mg per kg, others have written to me to let me know that they get great results at 60-70 mg per kg, but not at levels less than that. I personally found that around 30-60 mg per kg worked best for me, but that I can manage on 20 mg per kg.

      I hope this helps. If you have any more questions, please let me know. I’m here to help.

      Kind regards,


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: